Principle Roles & Responsibilities / Accountabilities
Perform preformulation research on NCE including but not limit to compound pharmaceutical profiling, physicochemical property and solid state characterization, polymorph/salt/co-crystal screening for phase-appropriate solid form selection.
Serve as a resident Preformulation expert, optimize the in-house capability to create innovative and efficient solutions to specific problems utilizing the state-of-the-art technologies and in-depth scientific knowledge and experience.
Set up and maintain solid state and formulation equipment including XRPD, DCS, TGA, PLM, DVS, PSD etc.; writing relevant instrument user manuals and reports.
Contribute to new chemical entity (NCE) developability evaluation from preformulation and formulation perspective.
Knowledge in preclinical Formulation development and supply to small molecules R&D projects would be a plus. This including the support of ongoing efficacy, DMPK, and toxicology studies; Make improvements on the existing formulations.
May represent the formulation function at cross functional project team on preformulation and formulation related matters and provide necessary support to project teams.
Other related duties may be assigned to meet team and site objectives.
Qualification and Experience
Advanced degree in a scientific or relevant discipline (Ph.D. or equivalent) or MS with at least 5 years’ working experience in formulation or related area.
Job Required Competencies
Demonstrated knowledge and experience for solid state characterization, pharmaceutical profiling, polymorph/salt/co-crystal screening. Capability for fully independent work in all these areas and Identify critical physicochemical liabilities & hot spots that may impact on development.
Solid knowledge on preformulation theories and the state-of-the-art technologies, and hands-on experience in operating, calibrating, maintaining and troubleshooting of a wide range of instruments (XRPD, DSC, TGA, PLM, DVS, PSD etc).
Knowledge on Formulation theories and technologies would be a plus.
Must be able to manage project; must possess strong problem solving and troubleshooting abilities. must be able to manage Preformulation project. Must be proactive and self-motivated.
Must be a good team player with good interpersonal communication skills.
Fluent in both written and spoken English; can deliver good presentations in English and Chinese